Eric Dane, Beloved Star of “Grey’s Anatomy, Passes Away at 53

Hollywood, CA – February 20, 2026 – Eric Dane, the charismatic actor who captivated audiences as Dr. Mark Sloan on the hit series “Grey’s Anatomy,” has died at the age of 53, his publicist confirmed. Dane passed away on Thursday afternoon after a courageous battle with amyotrophic lateral sclerosis (ALS).

In a heartfelt statement, his family shared, “With heavy hearts, we announce that Eric left us surrounded by his devoted wife, dear friends, and his two beautiful daughters, Billie and Georgia, who were the center of his world. Throughout his journey with ALS, Eric became a passionate advocate for awareness and research, determined to make a difference for others facing the same fight. He will be deeply missed and lovingly remembered always.”

Dane publicly revealed his diagnosis of ALS in 2025, using his platform to raise awareness and support for those affected by the disease. He was committed to advocating for research and assistance for neurodegenerative conditions, emphasizing the importance of community and hope.

His career began in the early 1990s, with memorable roles in popular series such as “The Wonder Years” and “Roseanne.” His breakout came with a multi-episode arc on “Gideon’s Crossing,” followed by a notable role as Jason Dean on “Charmed.” However, it was his portrayal of the charming and enigmatic Dr. Mark Sloan on “Grey’s Anatomy” that solidified his status as a television icon. Nicknamed “McSteamy,” Dane became a fan favorite, appearing from seasons 3 through 9, and reprising his role during the show’s 17th season in 2021.

Reflecting on his time on the show, Dane described it as “a magical time in my life” during an appearance on SiriusXM’s “Jess Cagle Show.” He cherished the connections he made and the excitement of being part of such a groundbreaking series.

Beyond television, Dane starred in films like “X-Men: The Last Stand,” “Marley & Me,” and “Burlesque.” More recently, he took on the role of Cal Jacobs in the acclaimed series “Euphoria,” showcasing his versatility as an actor. He was set to return for the show’s anticipated third season.

Despite his illness, Dane remained active in his career, appearing last fall in an episode of “Brilliant Minds,” where he played a firefighter battling ALS. His openness about his diagnosis resonated with many, as he shared the early symptoms that led to his condition, including weakness in his right hand.

Dane’s advocacy extended to Capitol Hill, where he joined the nonprofit I AM ALS to push for increased funding for research on neurodegenerative diseases. Reflecting on his hopes for the future, he expressed a desire to be present for significant milestones in his daughters’ lives, stating, “I want to see them graduate college, get married, and maybe have grandkids.”

The ALS community expressed their sorrow at his passing, with I AM ALS calling him “a fierce advocate, a generous spirit, and a true champion in the movement to end ALS.”

Eric Dane leaves behind a legacy of talent, compassion, and unwavering determination. His contributions to the entertainment industry and advocacy for those affected by ALS will not be forgotten.